Highrez

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XMBC Version: 2.19.2
Installed or Portable version: Installed
Windows Version: Windows 10 21H2
Mouse Information (brand/model): Logitech MX Master 2S
Relevant Computer Information (CPU, RAM etc): Beefy Lenovo laptop used for 3d work
Did the problem occur after an upgrade of XMBC? (If so, from what version?): No
Did the problem occur after a Windows update/upgrade? (If so, from what version?): No
How long have you used XMBC?: One week
What language and keyboard layout do you use in Windows?: English US

Clear description of the problem - try and include as much information as possible, including what button and mappings you are having problems with (if applicable).:

This mouse has a bunch of buttons, so didn't expect all of them to work. There's a button where your thumb rests that is a button (Can't see it in pictures.) When clicked, it causes the Windows application switcher to appear. So Windows definitely sees it. But no reaction from XMouse. Would love to program this button, and would also love not to load any Logitech software. Possible?

Sorry not possible.
It may be possible in the Logitech software, but the button is not exposed as a normal button to Windows so XMBC cant see it nor remap/disable it (The FAQ describes in more detail why XMBC only sees 5 buttons!)
Same for my Logitech M720

Regards,
Phil

Thanks, figured that was the answer, but thought maybe since it was causing the app switcher to pop-up, I might be missing something.

Yeh, thats the default for that button - it may only work when Logitech software is installed and I presume you can configure/disable it through the Logitech software (if its installed) - although I havn't tried recently.