The only real answer to that is to try it and see, but there are several tell tales signs. If you have a 5 button (or more) mouse and the 4th and 5th buttons perform back/next in your web browser then its almost certain XMBC will work for the first 5 buttons (XMBC does not support more than 5 buttons).
All I can say for sure is it works with the first 5 buttons of my Logitech MX518 Optical mouse, with or without the Logitech software installed.
It also works fine with my older (original) MS Intellimouse Optical Mouse and many other generic 4 and 5 button mice I have used.
NOTE: Some Logitech and Microsoft mice require either configuration through Logitech's software or Microsoft's mouse and keyboard center, and in some cases, MS's software can interfere with buttons 4 and 5, in that case, closing/removing the MS software often fixes it.
Please post here and tell others what what your mouse is and if XMBC works for you

Thanks,
Phil