Highrez

Wondering if I can make a macro like this with xmouse button.
When I press the button, It Press "A" , if I press the same button again , it will be "B"
And it will reset every 2.2 seconds.

Thanks

You may be able to do this with XMBC (although Autohotkey will be more powerful and probably reliable).
But i XMBC use simulated keystrokes, for the button on layer 1, use simulated keystrokes and type A{layer2}
For the same button on layer 2, use simulated keys and type B
On layer 2, set the option to "Switch to" layer 1 after 2 seconds (note: you cant specify in milliseconds here I'm afraid, so 2.2 seconds is out.)
You may be also able to type B{WAITMS2200}{layer1} on layer 2's simkeys. It also depends on if you want the key held down or simply pressed and released (play around with the send method in the simkeys dialog).

You are right, it's possible to do with XMBC to some degree. I read too fast and seen 'button' word as a key in my mind so I thought it's another post someone wants XMBC to react for keyboard as well.