Highrez

Here are some of my most important profiles, the rest are pretty standard with 1 or 2 simple button settings so not worth sharing.
I have to warn you that you can find that some of the settings are ridiculous - that is because I have tested something and left the settings so I could test it again in future versions. Or you may find different buttons/chords set to do exactly the same - that's because I have 3 different mice which I use with my laptop and only one of them is with 5 buttons and 4 directions wheel, the other 2 are with less buttons and I tried to make it possible to use them more efficiently.

These are my hotkeys:
Alt + 1, 2, 3, 4, 5 - Layer 1, 2, 3, 4, 5
Ctrl + ` - Open settings window
Ctrl + F1 - Enable/Disable XMBC
Shift + F1 - Toggle Debug mode

I pretty much like to set things in such way, that if I have to switch to another layer (2, 3, 4 or 5) - the setting in it ends up with {Layer:1} so it automatically switches back to layer 1 after the sequence I need is completed. It is very convenient. Also in excel I have chording RMB+LMB in layer 1 that ends up with {Layer:2}, at that point I enter a letter and again I do RMB+LMB which does the 2nd part of the sequence and switches back to layer 1.

That is the most that I can think of at the moment but if anyone have some questions about some setting I'll be happy to explain further

I've checked some settings in your profiles (finally), in excel i see that you use simkeys to do repetitive key actions like selecting copying etc.
But i don't know what mean tag {APPS}

Hovering over Start Button doesn;t work on Win7 but it's easy to specify the window:
Explorer.exe - button - Shell_TrayWnd
It's brilliant

Hey, my friend , sorry for the late response but I haven't checked this topic for a while.
Actually it took me a few moments to recall where I have used this {APPS} tag and what is the actual task of that sim keys macro
So this {APPS} tag simply opens the context menu, like RMB click. Most keyboards have such key and it is located somewhere between Right Alt and Right Ctrl keys. I use this tag because in this case I use arrow tags to navigate to the cell I need because each time it might be at different location on the screen and I can't use coordinates tag.